How to Implement MDM in 12 Weeks
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HIV-1 induces telomerase activity in monocyte-derived macrophages, possibly safeguarding one of its reservoirs.
Monocyte-derived macrophages (MDM) are widely distributed in all tissues and organs, including the central nervous system, where they represent the main part of HIV-infected cells. In contrast to activated CD4(+) T lymphocytes, MDM are resistant to cytopathic effects and survive HIV infection for a long period of time. The molecular mechanisms of how HIV is able to persist in macrophages are no...
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